Napabucasin, STAT3 inhibitor; Inhibitor of cancer cell stemness (TBI3442)
$104.00 – $414.00
STAT3 inhibitor; Inhibitor of cancer cell stemness
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3442-5MG | Yes | 5 MG | $104.00 | |||
TBI3442-25MG | Yes | 25 MG | $414.00 |
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Description
Product Details
Formal Name: 2-Acetylnsphtho[2,3-b]furan-4,9-dione
Alternate Names: BBI608
Molecular Formula: C14H8O4
Formula Weight: 240.21
CAS Number: 83280-65-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
STAT3 inhibitor; Inhibitor of cancer cell stemness
Functions
Inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types. Effective antitumor agent as a monotherapy or in combination with other agents such as taxol in mouse models. Clinical trials have demonstrated encouraging anti-tumor activity with the potential to suppress metastasis and prevent relapse in patients with various types of cancer. Overcomes cisplatin resistance in non-small cell lung cancer.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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