Myriocin (ISP-1), Blocks sphingolipid biosynthesis (TBI2088)
$108.00 – $342.00
Blocks sphingolipid biosynthesis
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2088-5MG | Yes | 5 MG | $108.00 | |||
TBI2088-25MG | Yes | 25 MG | $342.00 |
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Description
Product Details
Formal Name: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
Alternate Names: ISP-1
Molecular Formula: C21H39NO6
Formula Weight: 401.54
CAS Number: 35891-70-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Blocks sphingolipid biosynthesis
Functions
Myriocin is a fungal metabolite with potent immunosuppressant activity. It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide. It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 4 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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