MPEP HCl, Metabotropic glutamate receptor antagonist (TBI4007)
$63.00 – $252.00
Metabotropic glutamate receptor antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4007-5MG | Yes | 5 MG | $63.00 | |||
TBI4007-25MG | Yes | 25 MG | $252.00 |
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Description
Product Details
Formal Name: MPEP HCl
Molecular Formula: C14H11N·HCl
Formula Weight: 229.71
CAS Number: 219911-35-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Metabotropic glutamate receptor antagonist
Functions
MPEP is a potent (IC50 = 36 nM for quisqualate-stimulated phosphoinositide hydrolysis) and selective (over mGlu1b, -2, -3, -4a, -6, -7b, and -8a) antagonist of the metabotropic glutamate receptor subtype 5 (mGlu5). It is a positive allosteric modulator of human mGlu4. MPEP inhibition of mGlu5 has been studied for the treatment of many CNS disorders including Parkinson’s, Fragile X syndrome, and addiction.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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