Motolimod, TLR8 Agonist (TBI4920)
$144.00 – $531.00
TLR8 Agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4920-5MG | Yes | 5 MG | $144.00 | |||
TBI4920-25MG | Yes | 25 MG | $531.00 |
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Description
Product Details
Formal Name: 2-Amino-N,N-dipropyl-8-[4-(pyrrolidine-1-carbonyl)phenyl]-3H-1-benzapine-4-carboxamide
Alternate Names: VTX-2337
Molecular Formula: C28H34N4O2
Formula Weight: 458.61
CAS Number: 926927-61-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
TLR8 Agonist
Functions
Motolimod (926927-61-9) is a selective Toll-like receptor 8 (TLR8) agonist (EC50 = 100 nM). It stimulates the production of TNFα and IL-12 from monocytes and myeloid dendritic cells. Motolimod also stimulated IFNγ production from NK cells and increased their toxicity against K562 and ADCC by rituximab and trastuzumab. It induced apoptosis in monocytic myeloid-derived suppressor cells. Motolimod is being investigated in combination with other cancer immunotherapies. Motolimod has also been shown in induce secreted IL-1b and IL-8 via activation of the NLRP3 inflammasome.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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