Monocrotaline, Induces pulmonary fibrosis in animal models(TBI2872)
$90.00 – $198.00
Induces pulmonary fibrosis in animal models
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2872-50MG | Yes | 50 MG | $90.00 | |||
TBI2872-250MG | Yes | 250 MG | $198.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: (3R,4R,5R)-4,5,8,10,12,13,13aR,13bR-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
Alternate Names: Crotaline; MCT; NSC28693
Molecular Formula: C16H23NO6
Formula Weight: 325.36
CAS Number: 315-22-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Induces pulmonary fibrosis in animal models
Functions
Monocrotaline is a naturally occurring pyrrolizidine alkaloid used to create an animal model of pulmonary arterial hypertension (PAH). It can mimic several important aspects of human PAH including vascular remodeling, proliferation of smooth muscle cells, endothelial dysfunction, production of inflammatory cytokines and right ventricle failure. Induces endoplasmic reticulum stress in a rat model of PAH. Induces sinusoidal obstruction syndrome, a form of drug-induced liver injury. May be used to establish a mouse model of pulmonary fibrosis.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 250 MG, 50 MG |
---|
Be the first to review “Monocrotaline, Induces pulmonary fibrosis in animal models(TBI2872)”
You must be logged in to post a review.
Reviews
There are no reviews yet.