ML-297, GIRK activator (TBI1469)
$126.00 – $504.00
GIRK activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1469-5MG | Yes | 5 MG | $126.00 | |||
TBI1469-25MG | Yes | 25 MG | $504.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: N-(3.4-Difluorophenyl)-n’-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
Alternate Names: VU0456810
Molecular Formula: C17H14F2N4O
Formula Weight: 328.32
CAS Number: 1443246-62-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
GIRK activator
Functions
Selective GIRK ½ (Kir3.1/3.2) channel activator, IC50 = 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels. Displays antiseizure activity and decreases anxiety-related behavior without sedative or addictive effects. Reduces glucose- and IBMX-stimulated GLP-1 secretion with no effect on GIP in murine L and K cells. Brain penetrant.
Application Procedures
First dissolved in DMSO (up to 45 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “ML-297, GIRK activator (TBI1469)”
You must be logged in to post a review.
Reviews
There are no reviews yet.