Mirin, Mre11-Rad50-Nbs1 inhibitor (TBI1069)
$90.00 – $252.00
Mre11-Rad50-Nbs1 inhibitor
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI1069-5MG | Yes | 5 MG | $90.00 | |||
| TBI1069-25MG | Yes | 25 MG | $252.00 |
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Description
Product Details
Formal Name: 2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
Molecular Formula: C10H8N2O2S
Formula Weight: 220.30
CAS Number: 1198097-97-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Mre11-Rad50-Nbs1 inhibitor
Functions
Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex which functions as a DNA damage sensor and activates ataxia-telangiectasia mutated kinase (ATM), a DNA repair enzyme. Mirin blocks the 3’ and 5’ exonuclease activity of Mre11. It enhances the killing of glioblastoma cells after treatment with alkylating agents such as lomustine. A very useful tool for determining the involvement of Mre11 in DNA damage response.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
| SIZE (mg) | 25 MG, 5 MG |
|---|
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