MG-132, Proteasome inhibitor (TBI1309)
$90.00 – $360.00
Proteasome inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1309-5MG | Yes | 5 MG | $90.00 | |||
TBI1309-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: N-(Benzyloxycarbonyl)leucinylleucinylleucinal
Alternate Names: Z-Leu-Leu-Leu-CHO
Molecular Formula: C26H41N3O5
Formula Weight: 475.63
CAS Number: 133407-82-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 45 mg/ml), in DMF (up to 45 mg/ml), or in Ethanol (up to 45 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Proteasome inhibitor
Functions
Specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate). Also inhibits calpain (IC50=1.25 μM) Suppresses gastric cancer cell proliferation and induces macro-autophagy. Activates stress kinases and induces Hsp72. Induces neurite outgrowth. Blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM). Cell permeable.
Application Procedures
First dissolved in DMSO (up to 45 mg/ml), in DMF (up to 45 mg/ml), or in Ethanol (up to 45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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