MF-438, SCD1 inhibitor (TBI4558)
$108.00 – $450.00
SCD1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4558-5MG | Yes | 5 MG | $108.00 | |||
TBI4558-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: 2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole
Molecular Formula: C19H18F3N5OS
Formula Weight: 421.44
CAS Number: 921605-87-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
SCD1 inhibitor
Functions
MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50 = 2.3 nM. MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg). Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model. MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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