Methotrexate, Dihydrofolate reductase inhibitor; Inhibits DNA synthesis (TBI1260)
$90.00 – $270.00
Dihydrofolate reductase inhibitor; Inhibits DNA synthesis
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1260-100MG | Yes | 100 MG | $90.00 | |||
TBI1260-500MG | Yes | 500 MG | $270.00 |
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Description
Product Details
Formal Name: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Alternate Names: Amethopterin; CL-14377; NSC740
Molecular Formula: C20H22N8O5 ∙ xH2O
Formula Weight: 554.40
CAS Number: 133073-73-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 45 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Dihydrofolate reductase inhibitor; Inhibits DNA synthesis
Functions
A synthetic folic acid analog with immunosuppressant and cancer chemotherapeutic activity. Inhibits thymidylate synthetase and de novo purine synthesis. Displays beneficial effects in rheumatoid arthritis by inhibiting the production of cytokines induced by T-cell activation and stimulation of adenosine release. It is the classic disease-modifying antirheumatic drug (DMARD).
Application Procedures
First dissolved in DMSO (up to 45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 500 MG, 100 MG |
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