Maraviroc, CCR5 antagonist (TBI4260)
$106.00 – $394.00
CCR5 antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4260-5MG | Yes | 5 MG | $106.00 | |||
TBI4260-25MG | Yes | 25 MG | $394.00 |
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Description
Product Details
Formal Name: 4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
Alternate Names: UK-427,857
Molecular Formula: C29H41F2N5O
Formula Weight: 513.70
CAS Number: 376348-65-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
CCR5 antagonist
Functions
Potent and selective CCR5 antagonist with strong anti-HIV activity. Prevents HIV-1 gp120 binding to CCR5, preventing cell-cell fusion. Inhibited MIP-1a (IC50 = 3.3 nM), MIP-1b (IC50 = 7.2 nM), and RANTES (IC50 = 5.2 nM) binding to CCR5-expressing HEK-293 cells. Clinically useful antiretroviral drug. Many cancer cells express CCR5: Maraviroc blocks metastasis of basal breast and pancreatic cancer cells, induces cytotoxic and apoptotic effects in colorectal cancer cells, reduces metastatic tumor growth in lungs, and suppresses growth in acute ALL cells. CCR inhibition with maraviroc induces macrophage repolarization with anti-tumoral effects.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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