Manidipine dihydrochloride, L-type calcium channel blocker (TBI2045)
$54.00 – $108.00
L-type calcium channel blocker
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2045-20MG | Yes | 20 MG | $54.00 | |||
TBI2045-100MG | Yes | 100 MG | $108.00 |
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Description
Product Details
Formal Name: 5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
Alternate Names: CV-4093·2HCl; Franidipine·2HCl
Molecular Formula: C35H38N4O6·2HCl
Formula Weight: 683.60
CAS Number: 89226-75-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
L-type calcium channel blocker
Functions
Manidipine is a clinically useful antihypertensive. It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature. Manidipine has recently been found to be an inhibitor (IC50 = 4.8 µM) of the SARS-CoV-2 main protease, 3CLpro. It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 µM) via inhibition of the Immediate-Early 2 (IE2) protein.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 20 MG, 100 MG |
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