LY2603618, Chk1 inhibitor (TBI4123)
$135.00 – $495.00
Chk1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4123-5MG | Yes | 5 MG | $135.00 | |||
TBI4123-25MG | Yes | 25 MG | $495.00 |
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Description
Product Details
Formal Name: N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N’-(5-methyl-2-pyrazinyl)urea
Alternate Names: Rabusertib
Molecular Formula: C18H22BrN5O3
Formula Weight: 436.30
CAS Number: 911222-45-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Chk1 inhibitor
Functions
LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor. Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone. LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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