LNT 1, FEN1 inhibitor (TBI4036)
$126.00 – $414.00
FEN1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4036-5MG | Yes | 5 MG | $126.00 | |||
TBI4036-25MG | Yes | 25 MG | $414.00 |
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Description
Product Details
Formal Name: 1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione
Alternate Names: FEN1-IN-1
Molecular Formula: C15H12N2O5S
Formula Weight: 332.30
CAS Number: 824983-91-7
Purity: >97%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 15 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
FEN1 inhibitor
Functions
LNT 1 (824983-91-7) is a potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1). It showed similar potency in inhibiting exonuclease 1 (EXO1). Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.
Application Procedures
First dissolved in DMSO (up to at least 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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