LDN193189 HCl, ALK 2, 3 inhibitor (TBI4764)
$108.00 – $423.00
ALK 2, 3 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4764-5MG | Yes | 5 MG | $108.00 | |||
TBI4764-25MG | Yes | 25 MG | $423.00 |
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Description
Product Details
Formal Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, dihydrochloride
Alternate Names: DM-3189
Molecular Formula: C25H22N6·2HCl
Formula Weight: 479.40
CAS Number: 1062368-62-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO or in Water (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
ALK 2, 3 inhibitor
Functions
LDN-193189 HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation. Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells. LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.
Application Procedures
First dissolved in DMSO or in Water (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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