Larotrectinib, TRK inhibitor (pan) (TBI4832)
$117.00 – $405.00
TRK inhibitor (pan)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4832-5MG | Yes | 5 MG | $117.00 | |||
TBI4832-25MG | Yes | 25 MG | $405.00 |
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Description
Product Details
Formal Name: (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)pyrrolidine-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
Alternate Names: LOXO-101; ARRY-470
Molecular Formula: C21H22F2N6O2
Formula Weight: 428.44
CAS Number: 1223403-58-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
TRK inhibitor (pan)
Functions
Potent (IC50’s < 11 nM) inhibitor of tropomyosin receptor kinases A, B, and C (TrkA, B, and C). It is >100 fold selective against a panel of 229 kinases. Markedly attenuats bone cancer pain, and significantly blocks formation of neuroma-like structures and the sprouting of sensory nerve fibers. Larotrectinib caused substantial tumor regression in various cancers displaying TRK gene fusions and is the first tissue agnostic cancer drug approved by the FDA.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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