L524-0366, Fn14 antagonist (TBI1536)
$117.00 – $468.00
Fn14 antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1536-5MG | Yes | 5 MG | $117.00 | |||
TBI1536-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: (1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone
Molecular Formula: C13H13ClN4OS
Formula Weight: 308.79
CAS Number: 951612-19-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 14 mg/ml with warming) or in Ethanol (up to 2 mg/ml with warming).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Fn14 antagonist
Functions
Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 µM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. It completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics.
Application Procedures
First dissolved in DMSO (up to 14 mg/ml with warming) or in Ethanol (up to 2 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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