KNK437, HSP70 inhibitor (TBI5561)
$108.00 – $324.00
HSP70 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5561-5MG | Yes | 5 MG | $108.00 | |||
TBI5561-25MG | Yes | 25 MG | $324.00 |
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Description
Product Details
Formal Name: 3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Molecular Formula: C13H11NO4
Formula Weight: 245.20
CAS Number: 218924-25-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
HSP70 inhibitor
Functions
Inhibits constitutive and inducible HSP70 expression in non-stressed and heat-stressed cancer cells. Blocks geldanamycin-induced induction of HSP70 and inhibition of TGFß signaling. Inhibits leukocyte integrin α4ß7-mediated adhesion of T cells to mucosal addressin cell adhesion molecule 1 (MAdCAM-1), suggesting that HSP70 is essential for ß7 integrin signalling. Suppresses morphine analgesic tolerance in a rodent model (100 mg/Kg).
Application Procedures
First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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