JQ1 (+/-), Bromodomain inhibitor (TBI1361)
$117.00 – $468.00
Bromodomain inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1361-5MG | Yes | 5 MG | $117.00 | |||
TBI1361-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Molecular Formula: C23H25ClN4O2S
Formula Weight: 457.00
CAS Number: 1268524-69-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 9 mg/ml) or in Ethanol (up to 9 mg/ml) with warming.
Storage: RT
Stability: ≥ 1 year.
Applications
Bromodomain inhibitor
Functions
JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers.
Application Procedures
First dissolved in DMSO (up to 9 mg/ml) or in Ethanol (up to 9 mg/ml) with warming, then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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