JNJ-63533054, GPR139 agonist, suppresses morphine intake (TBI3880)
$126.00 – $468.00
GPR139 agonist, suppresses morphine intake
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3880-5MG | Yes | 5 MG | $126.00 | |||
TBI3880-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: (S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl) benzamide
Molecular Formula: C17H17ClN2O2
Formula Weight: 316.80
CAS Number: 1802326-66-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
GPR139 agonist, suppresses morphine intake
Functions
JNJ-63533054 is a potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS. Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands. Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents. Suppresses morphine intake in a mouse self-administration model.
Application Procedures
First dissolved in DMSO (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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