IU1, USP-14 inhibitor (TBI1197)
$90.00 – $360.00
USP-14 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1197-10MG | Yes | 10 MG | $90.00 | |||
TBI1197-50MG | Yes | 50 MG | $360.00 |
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Description
Product Details
Formal Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
Molecular Formula: C18H21FN2O
Formula Weight: 300.38
CAS Number: 314245-33-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
USP-14 inhibitor
Functions
Selective inhibitor of Usp14 (IC50<4 μM). Enhances proteasome activity and substrate proteolysis. Inhibits Dengue virus replication. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load. Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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