IPI-549, Selective PI3Kγ (TBI4827)
$90.00 – $315.00
Selective PI3Kγ
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4827-5MG | Yes | 5 MG | $90.00 | |||
TBI4827-25MG | Yes | 25 MG | $315.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: (S)-2-Amino-N-[1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Molecular Formula: C30H24N8O2
Formula Weight: 629.68
CAS Number: 1693758-51-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective PI3Kγ
Functions
IPI-549 is a potent and highly selective inhibitor of PI3K-γ in both biochemical (IC50 = 16 nM) and cellular (IC50 = 12.2 nM) assays. Macrophage PI3K-γ has been found to be a critical switch between immune stimulation and suppression. IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3K-γ inhibition via IPI-549. IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines. IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “IPI-549, Selective PI3Kγ (TBI4827)”
You must be logged in to post a review.
Reviews
There are no reviews yet.