Ipatasertib, Pan-Akt inhibitor (TBI4751)
$117.00 – $432.00
Pan-Akt inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4751-5MG | Yes | 5 MG | $117.00 | |||
TBI4751-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-yla,ino)propan-1-one
Alternate Names: GDC-0068; RG7440
Molecular Formula: C24H32ClN5O42
Formula Weight: 458.00
CAS Number: 1001264-89-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Pan-Akt inhibitor
Functions
Ipatasertib is a selective (against a panel of 230 kinases) and potent pan-Akt inhibitor (IC50s: Akt1 = 5 nM, Akt2 = 18 nM, Akt3 = 8 nM).1 It displayed efficacy in xenograft models of prostate, breast, ovarian, colorectal, non-small cell lung, glioblastoma, and melanoma cancers.2 In clinical trials.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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