IM-12, GSK-3β inhibitor (TBI5125)
$94.00 – $317.00
GSK-3β inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5125-5MG | Yes | 5 MG | $94.00 | |||
TBI5125-25MG | Yes | 25 MG | $317.00 |
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Description
Product Details
Formal Name: 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Molecular Formula: C22H20FN3O2
Formula Weight: 377.40
CAS Number: 1129669-05-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
GSK-3β inhibitor
Functions
A potent and selective inhibitor of glycogen synthase kinase 3β (GSK-3β) IC50=53 nM which induces neuronal differentiation. Activates the Wnt-β-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models. Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone. Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.
Application Procedures
First dissolved in DMSO (50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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