iCRT5, b-catenin inhibitor (TBI1371)
$103.00 – $410.00
b-catenin inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1371-5MG | Yes | 5 MG | $103.00 | |||
TBI1371-25MG | Yes | 25 MG | $410.00 |
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Description
Product Details
Formal Name: 2-[[5-Chloro-2-[4-[(4-methylpiperazine-1-yl)methyl]pyrimidine-4-yl]amino]-N,N-dimethylbenzenesulfonamide
Molecular Formula: C16H17NO5S2
Formula Weight: 367.44
CAS Number: 18623-44-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
b-catenin inhibitor
Functions
A selective CRT (β-catenin-responsive transcription) inhibitor. IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction. Displays poor inhibition of cell proliferation in triple-negative breast cancer cells. Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs. Modulators of Wnt signaling show great promise in animal models of several cancers. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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