Icilin, TRPM8 channel activator (TBI4380)
$117.00 – $441.00
TRPM8 channel activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4380-10MG | Yes | 10 MG | $117.00 | |||
TBI4380-50MG | Yes | 50 MG | $441.00 |
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Description
Product Details
Formal Name: 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one
Alternate Names: AG 3-5
Molecular Formula: C16H13N3O4
Formula Weight: 311.29
CAS Number: 36945-98-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
TRPM8 channel activator
Functions
Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8). Agonist at TRPM8 (EC50 = 0.2 µM) and ANKTM1(TRPA1). Agonist effects require Ca2+ and are pH dependent. Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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