Ibandronate, Farnesyl pyrophosphate synthase inhibitor (TBI4630)

Description

Product Details

Formal Name: (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid, sodium monohydrate

Alternate Names: BM-21.0955

Molecular Formula: C₉H₂₂NNaO₇P₂ • H2O

Formula Weight: 359.23

CAS Number: 138926-19-9

Purity: >98%

Formulation: powder

Solubility: Soluble in water (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

Farnesyl pyrophosphate synthase inhibitor

 

Functions

Clinically useful bisphosphonate for prevention and treatment of osteoporosis, and skeletal fractures in patients with cancer. Potent inhibitor of farnesyl pyrophosphate synthase (IC50 = 20 nM) and strongly binds hydroxyapatite (1/Kd = 2.4 µM), interfering with crystal growth, slowing resorption, and thereby maintaining bone strength.

 

Application Procedures

First dissolved in water (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	250 MG, 50 MG

TBI4630_Ibandronate