HTS01037, FABP inhibitor (TBI1453)
$108.00 – $432.00
FABP inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1453-5MG | Yes | 5 MG | $108.00 | |||
TBI1453-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 4-[(3-Carboxy-1-oxo-2-propen-1-yl)amino]-[2,2’-bithiophene]-5-carboxylic acid, 5-methyl ester
Molecular Formula: C14H11NO5S2
Formula Weight: 337.37
CAS Number: 682741-29-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
FABP inhibitor
Functions
Inhibits fatty acid binding proteins. Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. Acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophages. Inhibits FABP-dependent and fatty acid-stimulated leukotriene C4 biosynthesis. Reduces intracellular free fatty acid levels, lowering macrophage inflammation and ER stress3. Reduces LPS-stimulated IL-1β secretion in a mouse model. Inhibits VLDL-induced foam cell formation.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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