HPI-1, Hedgehog pathway inhibitor (TBI4522)
$117.00 – $441.00
Hedgehog pathway inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4522-5MG | Yes | 5 MG | $117.00 | |||
TBI4522-25MG | Yes | 25 MG | $441.00 |
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Description
Product Details
Formal Name: 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
Molecular Formula: C27H29NO6·xH20
Formula Weight: 463.52 (anhydrous)
CAS Number: 599150-20-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Hedgehog pathway inhibitor
Functions
HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50’s range from 0.2 to 6 µM for various cell-based assays.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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