Honokiol-DCA, TRAP1 inhibitor (TBI3596)
$126.00 – $504.00
TRAP1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3596-5MG | Yes | 5 MG | $126.00 | |||
TBI3596-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: Honokiol bis-dichloroacetate
Alternate Names: HDCA
Molecular Formula: C22H18Cl4O4
Formula Weight: 488.20
CAS Number: 1620160-42-0
Purity: >98%
Formulation: oil
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
TRAP1 inhibitor
Functions
Synthetic bis-dichloroacetate ester of the natural product honokiol, is an allosteric inhibitor of the mitochondrial chaperone TRAP1. It binds to an allosteric site on TRAP1 leading to inhibition (IC50 ~8µM) and is selective over HSP90, unlike 17-AAG and radicicol which are nonselective. Inhibition of TRAP1 leads to upregulation of succinate dehydrogenase and the mitochondrial deacetylase SIRT3. In neoplastic cells HDCA decreases proliferation, increases mitochondrial superoxide levels and abolishes tumorigenic growth. HDCA demonstrated in vivo activity against vemurafenib-resistant (LM36R) melanoma.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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