H-151, STING antagonist (TBI4132)
$117.00 – $432.00
STING antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4132-10MG | Yes | 10 MG | $117.00 | |||
TBI4132-50MG | Yes | 50 MG | $432.00 |
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Description
Product Details
Formal Name: N-(4-Ethylphenyl)-N’-1H-indol-3-yl urea
Molecular Formula: C17H17N3O
Formula Weight: 279.34
CAS Number: 941987-60-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
STING antagonist
Functions
H-151 is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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