GSK2334470, Selective PDK1 (PDPK1) inhibitor (TBI4725)
$106.00 – $441.00
Selective PDK1 (PDPK1) inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4725-5MG | Yes | 5 MG | $106.00 | |||
TBI4725-25MG | Yes | 25 MG | $441.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
Alternate Names: GSK-470
Molecular Formula: C25H34N8O
Formula Weight: 462.60
CAS Number: 1227911-45-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (40 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective PDK1 (PDPK1) inhibitor
Functions
Inhibits ‘master kinase’ PDK1 (3-phosphoinositide-dependent protein kinase, PDPK1), potently (IC50 = 10 nM) and specifically (5 µm does not inhibit even closely related kinases). GSK2334470 thus blocks activation of protein kinases (PK) A, G, and C, and further downstream, Akt, S6K, and mTORC1. Inhibits ferroptosis, and shows antitumor activity in multiple myeloma, prostate, and other cancers.
Application Procedures
First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “GSK2334470, Selective PDK1 (PDPK1) inhibitor (TBI4725)”
You must be logged in to post a review.
Reviews
There are no reviews yet.