Griseofulvin, Centrosomal clustering inhibitor (TBI2745)

Description

Product Details

Formal Name: Fermentation product from Penicillium sp.

Molecular Formula: C₁₇H₁₇ClO₆

Formula Weight: 352.77

CAS Number: 126-07-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml), in DMF (up to 50 mg/ml), or in Ethanol (up to 5 mg/ml).

Storage: RT

Stability: ≥ 1 year.

 

Applications

Centrosomal clustering inhibitor

 

Functions

Antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the cytoplasm to the nucleus. Inhibits the growth of adrenocortical cancer cells in vitro.  Inhibits centrosome clustering, induces spindle multipolarity, mitotic arrest and cell death in multiple tumor cell lines but not in diploid fibroblasts and keratinocytes with normal centrosome content.

 

Application Procedures

First dissolved in DMSO (up to 40 mg/ml), in DMF (up to 50 mg/ml), or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	500 MG, 100 MG

TBI2745_Griseofulvin