Glumetinib, c-Met inhibitor (highly selective) (TBI4690)
$162.00 – $585.00
c-Met inhibitor (highly selective)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4690-5MG | Yes | 5 MG | $162.00 | |||
TBI4690-25MG | Yes | 25 MG | $585.00 |
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Description
Product Details
Formal Name: 6-(1-Methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridine-3-yl]sulfonylpyrazolo[4,3-b]pyridine
Alternate Names: SCC244
Molecular Formula: C21H17N9O2S
Formula Weight: 459.50
CAS Number: 1642581-63-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
c-Met inhibitor (highly selective)
Functions
Highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-Met kinase. It induced tumor regression in MET-driven CDX (MKN-45, SNU-5, EBC-1) and PDX (4 NSCLC, 5 HCC) tumor models.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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