Galunisertib, TGFß receptor 1 inhibitor / Cancer immunotherapeutic (TBI4110)
$81.00 – $252.00
TGFß receptor 1 inhibitor / Cancer immunotherapeutic
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4110-5MG | Yes | 5 MG | $81.00 | |||
TBI4110-25MG | Yes | 25 MG | $252.00 |
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Description
Product Details
Formal Name: 4-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
Alternate Names: LY2157299
Molecular Formula: C22H19N5O
Formula Weight: 369.40
CAS Number: 700874-72-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
TGFß receptor 1 inhibitor / Cancer immunotherapeutic
Functions
Galunisertib is a TGF-β kinase (TGFBR1, ALK5) inhibitor (IC50 = 56 nM). Blocks TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells. Clinically useful anticancer agent, and is a promising co-treatment with immune checkpoint inhibitors.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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