GAC Inhibitor 968, Glutaminase C inhibitor (TBI1538)
$90.00 – $360.00
Glutaminase C inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1538-5MG | Yes | 5 MG | $90.00 | |||
TBI1538-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]-phenanthridin-4(1H)-one
Molecular Formula: C27H27BrN2O
Formula Weight: 475.40
CAS Number: 311795-38-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to (11 mg/ml); or ethanol (up to 1 mg/ml, warm)
Storage: RT
Stability: ≥ 2 years.
Applications
Glutaminase C inhibitor
Functions
Allosteric inhibitor of glutaminase C (GAC). Inhibition of GAC blocks oncogenic transformation induced by Rho GTPases in fibroblasts and B lymphoma cells with no effect on normal cells. Inhibits liver-type glutaminase GLS2 and suppresses breast tumor growth in vivo. Reverses acquired erlotinib resistance in non-small cell lung cancer.
Application Procedures
First dissolved in DMSO (up to (11 mg/ml); or ethanol (up to 1 mg/ml, warm), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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