FQI1, LSF ligand (TBI1360)
$126.00 – $504.00
LSF ligand
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1360-5MG | Yes | 5 MG | $126.00 | |||
TBI1360-25MG | Yes | 25 MG | $504.00 |
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Description
Product Details
Formal Name: 8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6(5H)-one
Molecular Formula: C18H17NO4
Formula Weight: 311.33
CAS Number: 599151-35-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
LSF ligand
Functions
Inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity. In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1. Blocks LSF-stimulated activation of DNA methyltransferase 1. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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