Flavopiridol HCl (Alvocidib), CDK inhibitor (TBI3063)
$90.00 – $360.00
CDK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3063-5MG | Yes | 5 MG | $90.00 | |||
TBI3063-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one, hydrochloride
Alternate Names: L 86-8275; Alvocidib; NSC-649890
Molecular Formula: C21H20ClNO5 HCl
Formula Weight: 438.30
CAS Number: 131740-09-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Water (up to 40 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
CDK inhibitor
Functions
Cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase. Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells. Potentiates the effects of topoisomerase I inhibitors by suppressing Rad51 expression in a p53-dependent manner. Displays potent antiviral activity against HIV-1 and HSV-1 in vitro.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Water (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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