FIN56, Squalene synthase activator / GPX4 degradation (TBI4666)
$117.00 – $423.00
Squalene synthase activator / GPX4 degradation
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4666-5MG | Yes | 5 MG | $117.00 | |||
TBI4666-25MG | Yes | 25 MG | $423.00 |
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Description
Product Details
Formal Name: N2,N7-Dicyclohexyl-9-hydroxyiminofluorene-2,7-disulfonamide
Alternate Names: Ferroptosis inducing 56
Molecular Formula: C25H31N3O5S2
Formula Weight: 517.70
CAS Number: 1083162-61-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Squalene synthase activator / GPX4 degradation
Functions
Novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism). FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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