Exo2, GBF1 inhibitor; Induces Golgi disassembly
$112.00 – $446.00
GBF1 inhibitor; Induces Golgi disassembly
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1594-5MG | Yes | 5 MG | $112.00 | |||
TBI1594-25MG | Yes | 25 MG | $446.00 |
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Description
Product Details
Formal Name: 2-Methoxy-4-[(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
Molecular Formula: C18H18N4O2S
Formula Weight: 354.43
CAS Number: 304684-77-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
GBF1 inhibitor; Induces Golgi disassembly
Functions
Exo2 disrupts the Golgi apparatus and stimulates Golgi-ER fusion in mammalian cells. May be used to completely ablate the Golgi apparatus. Like brefeldin A (BFA), it inhibits anterograde transport and disrupts morphology of the trans-Golgi network (TGN) but unlike BFA, it does not induce tubulation and merging of the TGN and endosomal compartments. It perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network, in contrast to cholera toxin. Accelerates degradation of perilipin-2 proteins.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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