EX-527, SIRT1 inhibitor (TBI1083)

Description

Product Details

Formal Name: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Molecular Formula: C₁₃H₁₃ClN₂O

Formula Weight: 248.71

CAS Number: 49843-98-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 18 mg/ml) or in Ethanol (up to 10 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

SIRT1 inhibitor

 

Functions

Selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.

 

Application Procedures

First dissolved in DMSO (up to 18 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Additional information

SIZE (mg)	25 MG, 5 MG

Datasheet:

TBI1083_EX-527

MSDS:

TBI1083_EX-527_MSDS_2024