DAPT, g-secretase inhibitor (TBI4514)
$108.00 – $351.00
g-secretase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4514-5MG | Yes | 5 MG | $108.00 | |||
TBI4514-25MG | Yes | 25 MG | $351.00 |
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Description
Product Details
Formal Name: N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
Alternate Names: LY-374973
Molecular Formula: C23H26F2N2O4
Formula Weight: 432.46
CAS Number: 208255-80-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 18 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
g-secretase inhibitor
Functions
Inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically). Oral administration of DAPT has been shown to reduce levels of Aβ in brain extract, cerebrospinal fluid and plasma from mice and rats. DAPT blocks Notch signaling which promotes neuronal differentiation of precur-sor cells. Enhances iPS cells without oncogenes KLF and CMYC. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 18 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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