Candesartan, Angiotensin AT1 receptor antagonist (TBI2049)

Description

Product Details

Formal Name: 2-Ethoxy-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid

Alternate Names: CV-11974

Molecular Formula: C₂₄H₂₀N₆O₃

Formula Weight: 400.45

CAS Number: 139481-59-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

Angiotensin AT1 receptor antagonist

 

Functions

Angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively. Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2α or endothelin. Prevents astrocyte and microglial activation and neuroinflammation and improves hippocampal neurogenesis. Attenuates angiogenesis in hepatocellular carcinoma. Clinically useful antihypertensive agent. Ameliorates brain inflammation associated with Alzheimer’s disease. Active in vivo and orally active.

 

Application Procedures

First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Additional information

SIZE (mg)	250 MG, 50 MG

TBI2049_Candesartan