C-DIM 12, NFkB inhibitor; Nurr1 inhibitor (TBI3280)
$99.00 – $324.00
NFkB inhibitor; Nurr1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3280-5MG | Yes | 5 MG | $99.00 | |||
TBI3280-25MG | Yes | 25 MG | $324.00 |
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Description
Product Details
Formal Name: 3,3’-[(4-Chlorophenyl)methylene]bis[1H-indole]
Molecular Formula: C23H17ClN2
Formula Weight: 356.85
CAS Number: 178946-89-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
NFkB inhibitor; Nurr1 inhibitor
Functions
Activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses inflammatory signaling in these cells. Displays neuroprotective activity in a mouse model of progressive neurodegeneration with a strong neuroinflammatory component (50 mg/Kg, oral).
Application Procedures
First dissolved in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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