Bortezomib, Proteasome inhibitor (TBI2120)
$99.00 – $315.00
Proteasome inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2120-5MG | Yes | 5 MG | $99.00 | |||
TBI2120-25MG | Yes | 25 MG | $315.00 |
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Description
Product Details
Formal Name: N-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid
Alternate Names: MG-341; PS-341; MLN341
Molecular Formula: C19H25BN4O4
Formula Weight: 384.20
CAS Number: 179324-69-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 35 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Proteasome inhibitor
Functions
Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNFα synthesis and FGF-induced angiogenesis. Clinically useful agent for treatment of multiple myeloma. Shows promise in the treatment of neurodegenerative diseases in which low-expressing proteins such as IKAP/hELP1 in familial dysautonomia are preserved. Reversible. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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