Boceprevir, Antiviral; SARS-CoV-2 Mpro inhibitor (TBI5087)
$126.00 – $450.00
Antiviral; SARS-CoV-2 Mpro inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5087-5MG | Yes | 5 MG | $126.00 | |||
TBI5087-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: (1R,2S,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-3-azabicyclo[3.1.0]hexane-2-carboxamide
Alternate Names: SCH 503034
Molecular Formula: C27H45N5O5
Formula Weight: 519.7
CAS Number: 394730-60-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 15 mg/ml); or Ethanol (25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Antiviral; SARS-CoV-2 Mpro inhibitor
Functions
Boceprevir directly inhibits Hepatitis C virus (HCV) NS3 protease (overall binding constant for formation of covalent adduct, Ki* = 14 nM; initial inhibition constant Ki = 7.8 µM). This blocks NS3 autoactivation, and subsequent cleavage and maturation of other viral proteins necessary for replisome assembly. This reversible, slow-binding ketoamide also restores host interferon signaling obstructed by HCV, thus reactivating the immune response. Recently, it was also found to inhibit the key SARS-CoV-2 protease, Mpro (3CLpro) in vitro (Ki = 1.18 µM) and in cells (EC50 = 1.9 µM, virus-induced cytopathic effects (CPE)
Application Procedures
First dissolved in DMSO (up to at least 15 mg/ml); or Ethanol (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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