BI-6015, HNF4a inhibitor (TBI1402)
$90.00 – $360.00
HNF4a inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1402-5MG | Yes | 5 MG | $90.00 | |||
TBI1402-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
Molecular Formula: C15H13N3O4S
Formula Weight: 331.35
CAS Number: 93987-29-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
HNF4a inhibitor
Functions
Hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis. BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics. Represents the first small molecule tool for pharmacologic modulation of HNF4α activity. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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