Bexarotene, Retinoid RXR agonist (TBI2121)
$72.00 – $324.00
Retinoid RXR agonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2121-10MG | Yes | 10 MG | $72.00 | |||
TBI2121-50MG | Yes | 50 MG | $324.00 |
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Description
Product Details
Formal Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Alternate Names: LGD-1069; SR-11247
Molecular Formula: C24H28O2
Formula Weight: 348.49
CAS Number: 153559-49-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Retinoid RXR agonist
Functions
A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively). Clinically useful antineoplastic agent for cutaneous T-cell lymphoma Causes complete regression of mammary carcinoma. Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability. Reverses apoE4-driven brain pathology and behavioral deficits in vivo.
Application Procedures
First dissolved in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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