BAY 87-2243, HIF-1 / Mitochondrial complex I inhibitor (TBI4910)
$108.00 – $405.00
HIF-1 / Mitochondrial complex I inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4910-5MG | Yes | 5 MG | $108.00 | |||
TBI4910-25MG | Yes | 25 MG | $405.00 |
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Description
Product Details
Formal Name: 5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Molecular Formula: C26H26F3N7O2
Formula Weight: 525.54
CAS Number: 1227158-85-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
HIF-1 / Mitochondrial complex I inhibitor
Functions
Potently inhibits HIF-1 reporter gene activity (IC50 = 0.7 nM) and CA9 protein expression (IC50 = 2.0 nM). Blocked HIF-1α and HIF-2α protein accumulation in hypoxic H460 cells, and reduced tumor weight in nude mice inoculated with H460 cells. BAY 87-2243 strongly inhibits mitochondrial complex I activity (IC50 = 10 nM in mitochondria isolated from PC3 cells) leading to its HIF-1 effects. It has no effect on mitochondrial complex III. Reduces melanoma tumor growth via its targeting of mitochondrial complex I.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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