BADGE, PPARg antagonist (TBI2618)
$54.00 – $180.00
PPARg antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2618-10MG | Yes | 10 MG | $54.00 | |||
TBI2618-50MG | Yes | 50 MG | $180.00 |
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Description
Product Details
Formal Name: 2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane
Alternate Names: Bisphenol A diglycidyl ether
Molecular Formula: C21H24O4
Formula Weight: 340.41
CAS Number: 1675-54-3
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
PPARg antagonist
Functions
PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model. Induces apoptosis via PPARγ-independent mechanisms. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism. Increases osteoblastogenesis and bone mass in a mouse model. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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